Nossa equipe de neurologistas, psiquiatras, biólogos, psicólogos e outros especialistas estudam o desenvolvimento do sistema nervoso e seu funcionamento em condições normais e patológicas.
A pesquisa em neurociências é um dos carros-chefe do IDOR, desde a sua concepção. Uma das principais vertentes dessa área de pesquisa é o uso de células reprogramadas e organoides cerebrais para estudo do desenvolvimento e de doenças que acometem o sistema nervoso central. Células epiteliais extraídas da urina ou da pele de voluntários são induzidas a voltar ao estágio embrionário de células-tronco, capazes de se transformar em qualquer tecido humano, incluindo células do cérebro. Cultivadas em laboratório, essas células formam organoides cerebrais – também conhecidos como mini-cérebros – que permitem estudar em detalhe o desenvolvimento do sistema nervoso central e, também, o impacto de vírus como Zika e Sars-Cov-2, a manipulação de genes e os efeitos de medicamentos sobre o funcionamento do tecido nervoso.
Outra linha de pesquisa importante desenvolvida pelo IDOR na área neurociência é a de neuroimagem, em particular aplicada ao estudo da plasticidade cerebral, isto é, da capacidade que o cérebro humano tem de se adaptar a situações adversas. A integração entre os resultados de exames de imagens e dados clínicos, genéticos e laboratoriais permite estudar as doenças do sistema nervoso central de forma aprofundada, em três vertentes principais: doenças do neurodesenvolvimento, reabilitação e plasticidade no envelhecimento.
Com uso de exames de ressonância magnética funcional, os pesquisadores conseguem identificar as rotas de conexão entre as diferentes partes do cérebro saudável e em situações patológicas. Entre as condições estudadas estão a disgenesia do corpo caloso, os acidentes vasculares cerebrais e a síndrome do membro fantasma, que pode surgir após uma amputação.
Cientistas do IDOR estudam, ainda, novas técnicas capazes de ajudar pacientes a recuperarem suas funções cerebrais. Uma das técnicas estudadas é o neurofeedback, que usa a ressonância magnética funcional para mostrar aos pacientes sua atividade cerebral e estimulá-los a controlar essa atividade.
O estudo de transtornos de aprendizagem e possíveis intervenções também faz parte do rol de pesquisas do IDOR voltadas à neurociência. Um exemplo é o desenvolvimento de um software que visa auxiliar crianças neurotípicas e com dislexia e outros transtornos no aprendizado da leitura.
No Centro de Neuropsicologia Aplicada (CNA), o IDOR combina pesquisa científica e atendimento clínico, oferecendo serviço de investigação neuropsicológica a crianças, adolescentes e adultos com suspeita de transtornos de aprendizagem e atenção, problemas comportamentais e dificuldades de memória, entre outros. A equipe multidisciplinar do CNA lidera projetos de pesquisa sobre transtorno do déficit de atenção com hiperatividade e doença de Alzheimer.
Pesquisadores
Daniel Martins-de-Souza
Neurociência
Erika de Carvalho Rodrigues
Neurociência
Felipe Kenji Sudo
Neurociência
Fernanda Freire Tovar-Moll
Neurociência
Processamento e análise de imagens
Fernanda G. De Felice
Neurociência
Jorge Moll
Neurociência
Processamento e análise de imagens
Juliana Caldas
Neurociência
Terapia intensiva
Leonardo F. Fontenelle
Neurociência
Luiz E. Mello
Neurociência
Marília Zaluar Passos Guimarães
Neurociência
Paulo Mattos
Neurociência
Ricardo de Oliveira Souza
Neurociência
Roberto Lent
Neurociência
Ronald Fischer
Neurociência
Sergio T. Ferreira
Neurociência
Stevens Rehen
Neurociência
Suzete Farias da Guarda
Neurociência
Principais Publicações
Veja as principais publicações relacionadas a oncologia
Salerno JA, Rehen S. Human pluripotent stem cells as a translational toolkit in psychedelic research in vitro. iScience. 2024 Mar 28;27(5):109631. doi: 10.1016/j.isci.2024.109631. PMID: 38628967; PMCID: PMC11019282.
N. Costa M, Goto-Silva L, M. Nascimento J, Domith I, Karmirian K, Feilding A, Trindade P, Martins-de-Souza D, K. Rehen S. LSD Modulates Proteins Involved in Cell Proteostasis, Energy Metabolism and Neuroplasticity in Human Cerebral Organoids. ACS Omega. (2024).
Ornelas IM, Carrilho BS, Ventura MAVC, Domith I, de V Silveira CM, Dos Santos VF, Delou JM, Moll F, Pereira HMG, Junqueira M, Aguilaniu H, Rehen S. Lysergic acid diethylamide induces behavioral changes in Caenorhabditis elegans. Neurosci Lett. 2024 Aug 10;837:137903. doi: 10.1016/j.neulet.2024.137903. Epub 2024 Jul 20. PMID: 39025433.
Ornelas IM, Cini FA, Wießner I, Marcos E, Araújo DB, Goto-Silva L, Nascimento J, Silva SRB, Costa MN, Falchi M, Olivieri R, Palhano-Fontes F, Sequerra E, Martins-de-Souza D, Feilding A, Rennó-Costa C, Tófoli LF, Rehen SK, Ribeiro S. Nootropic effects of LSD: Behavioral, molecular and computational evidence. Exp Neurol. 2022 Oct;356:114148. doi: 10.1016/j.expneurol.2022.114148. Epub 2022 Jun 19. PMID: 35732217.
Karmirian K, Holubiec M, Goto-Silva L, Fernandez Bessone I, Vitória G, Mello B, Alloatti M, Vanderborght B, Falzone TL, Rehen S. Modeling Alzheimer’s Disease Using Human Brain Organoids. Methods Mol Biol. 2023;2561:135-158. doi: 10.1007/978-1-0716-2655-9_7. PMID: 36399268.
Fischer, R. & Pilati, R. (2024). A Psicologia do Jeitinho Brasileiro [The psychology of the Brazilian jeitinho]. Brasilia: Editora UnB. https://livros.unb.br/index.php/portal/catalog/book/594
Bernardes, G., Bozza, B., Motta, M., Mattos, P. & Fischer, R. (2025) Semantic meaning means a lot: Exploring the role of semantics in the development of a Big Five taxonomy. Journal of Research in Personality. https://doi.org/10.1016/j.jrp.2024.104570
Fischer, R., & Rudnev, M. (2024). From MIsgivings to MIse-en-scène: The role of invariance in personality science. European Journal of Personality, https://doi.org/10.1177/08902070241283081
Fischer, R., Bailey, Y., Shankar, M., Safaeinili, N., Karl, J., Daly, A., Johnson, F. N., Winter, T., Arahanga-Doyle, H., Fox, R., & others. (2024). Cultural challenges for adapting behavioral intervention frameworks: A critical examination from a cultural psychology perspective. Clinical Psychology Review, 110:102425. doi: 10.1016/j.cpr.2024.102425.
Maraldi, E. O., Taves, A., Moll, J., Hartle, L., Moreira-de-Oliveira, M. E., Bortolini, T., & Fischer, R. (2024). Nonordinary Experiences, Well-being and Mental Health: A Systematic Review of the Evidence and Recommendations for Future Research. Journal of Religion and Health, 63(1), 410–444.
Farias DA Guarda SN, Santos JPS, Reis MSM, Passos RDH, Correia LC, Caldas JR, Gobatto ALN, Teixeira M, Oliveira A, Ribeiro MP, Batista PBP, Calderaro M, Paschoal Junior F, Pontes-Neto OM, Ramos JGR. Realistic simulation is associated with healthcare professionals’ increased self-perception of confidence in providing acute stroke care: a before-after controlled study. Arq Neuropsiquiatr. 2021 Jan;79(1):2-7. doi: 10.1590/0004-282X-anp-2019-0369. PMID: 33656107.
Caldas JR, Passos RH, Ramos JGR, Ramalho C, Sancho LS, Salinet AM, Farias S, Gobatto A, Bombonato G, Benigno P, Taccone FS, Panerai RB. Dynamic Autoregulation is Impaired in Circulatory Shock. Shock. 2020 Aug;54(2):183-189. doi: 10.1097/SHK.0000000000001488. PMID: 31764617.
Ramos JGR, da Hora Passos R, Teixeira MB, Gobatto ALN, Coutinho RVDS, Caldas JR, da Guarda SF, Ribeiro MP, Batista PBP. Prognostic ability of quick-SOFA across different age groups of patients with suspected infection outside the intensive care unit: A cohort study. J Crit Care. 2018 Oct;47:178-184. doi: 10.1016/j.jcrc.2018.07.008. Epub 2018 Jul 7. PMID: 30005305.
Farias da Guarda SN, Conforto AB. Effects of somatosensory stimulation on corticomotor excitability in patients with unilateral cerebellar infarcts and healthy subjects – preliminary results. Cerebellum Ataxias. 2014 Nov 5;1:16. doi: 10.1186/s40673-014-0016-5. Erratum in: Cerebellum Ataxias. 2016;3:11. PMID: 26331040; PMCID: PMC4552362.
Manto M, Bower JM, Conforto AB, Delgado-García JM, da Guarda SN, Gerwig M, Habas C, Hagura N, Ivry RB, Mariën P, Molinari M, Naito E, Nowak DA, Oulad Ben Taib N, Pelisson D, Tesche CD, Tilikete C, Timmann D. Consensus paper: roles of the cerebellum in motor control–the diversity of ideas on cerebellar involvement in movement. Cerebellum. 2012 Jun;11(2):457-87. doi: 10.1007/s12311-011-0331-9. PMID: 22161499; PMCID: PMC4347949.
Gonçalves RA, Sudo FK, Lourenco MV, Drummond C, Assunção N, Vanderborght B, Ferreira DDP, Ribeiro FC, Pamplona FA, Tovar-Moll F, Mattos P, Ferreira ST, De Felice FG. Cerebrospinal fluid irisin and lipoxin A4 are reduced in elderly Brazilian individuals with depression: Insight into shared mechanisms between depression and dementia. Alzheimers Dement. 2022. doi: 10.1002/alz.12893. Epub ahead of print.
Pamplona FA, Vitória G, Sudo FK, Ribeiro FC, Isaac AR, Moraes CA, Chauvet MG, Ledur PF, Karmirian K, Ornelas IM, Leo LM, Paulsen B, Coutinho G, Drummond C, Assunção N, Vanderborght B, Canetti CA, Castro-Faria-Neto HC, Mattos P, Ferreira ST, Rehen SK, Bozza FA, Lourenco MV, Tovar-Moll F. Age-linked suppression of lipoxin A4 associates with cognitive deficits in mice and humans. Transl Psychiatry. 2022;12(1):439. doi: 10.1038/s41398-022-02208-1.
Mendonca F, Sudo FK, Santiago-Bravo G, Oliveira N, Assuncao N, Rodrigues F, Soares R, Calil V, Bernardes G, Erthal P, Drummond C, Tovar-Moll F, Mattos P. Mild Cognitive Impairment or Attention-Deficit/Hyperactivity Disorder in Older Adults? A Cross Sectional Study. Front Psychiatry. 2021;12:737357. doi: 10.3389/fpsyt.2021.737357
Sudo FK, de Souza AS, Drummond C, Assuncao N, Teldeschi A, Oliveira N, Rodrigues F, Santiago-Bravo G, Calil V, Lima G, Erthal P, Bernardes G, Monteiro M, Tovar-Moll F, Mattos P. Inter-method and anatomical correlates of episodic memory tests in the Alzheimer’s Disease spectrum. PLoS One. 2019;14(10):e0223731. doi: 10.1371/journal.pone.0223731.
Drummond C, Coutinho G, Monteiro MC, Assuncao N, Teldeschi A, de Souza AS, Oliveira N, Bramati I, Sudo FK, Vanderboght B, Brandao CO, Fonseca RP, de Oliveira-Souza R, Moll J, Mattos P, Tovar-Moll F. Narrative impairment, white matter damage and CSF biomarkers in the Alzheimer’s disease spectrum. Aging (Albany NY). 2019;11(20):9188-9208. doi: 10.18632/aging.102391.
ALLAHDADI, K. J.; Hannan, Johanna L.; Tostes, Rita C.; Webb, R. Clinton. Endothelin-1 Induces Contraction of Female Rat Internal Pudendal and Clitoral Arteries through ET Receptor and Rho-Kinase Activation. The Journal of Sexual Medicine , p.2096 – 2103, 2010.
Allahdadi KJ, Walker BR, Kanagy NL. Augmented endothelin vasoconstriction in intermittent hypoxia-induced hypertension. Hypertension. 2005 Apr;45(4):705-9. Epub 2005 Feb 28. PMID: 15738350.
Marques-da-Silva, C; Chaves, MM; Castro, NG; Coutinho-Silva, R; Guimaraes, MZP Colchicine inhibits cationic dye uptake induced by ATP in P2X2 and P2X7 receptor-expressing cells: implications for its therapeutic action. British Journal of Pharmacology. , v.163, p.912 – 926, 2011.
Pamplona, F. A.; Ferreira, J.; Menezes De Lima, O.; Duarte, F. S.; Bento, A. F.; Forner, S.; Villarinho, J. G.; Bellochio, L.; Wotjak, C. T.; Lerner, R.; Monory, K.; Lutz, B.; Canetti, C.; Matias, I.; Calixto, J. B.; Marsicano, G.; Guimaraes, M. Z. P.; Takahashi, R. N. Anti-inflammatory lipoxin A4 is an endogenous allosteric enhancer of CB1 cannabinoid receptor. Proceedings of the National Academy of Sciences of the United States of America (Online). , v.109, p.21134 – 21139, 2012.
Sartore, Rafaela C.; Cardoso, Simone C.; Lages, Yury V.M.; Paraguassu, Julia M.; Stelling, Mariana P.; Madeiro Da Costa, Rodrigo F.; Guimaraes, Marilia Z.; Pérez, Carlos A.; Rehen, Stevens K. Trace elements during primordial plexiform network formation in human cerebral organoids. PeerJ. , v.5, p.e2927 – , 2017.
Guimarães, Marília Z. P.; De Vecchi, Rodrigo; Vitória, Gabriela; Sochacki, Jaroslaw K.; Paulsen, Bruna S.; Lima, Igor; Rodrigues Da Silva, Felipe; Da Costa, Rodrigo F. M.; Castro, Newton G.; Breton, Lionel; Rehen, Stevens K. Generation of iPSC-Derived Human Peripheral Sensory Neurons Releasing Substance P Elicited by TRPV1 Agonists. Frontiers in Molecular Neuroscience. , v.11, p.1 – 17, 2018.
Pedrosa, C. S. G.; Goto-Silva, L.; Temerozo, J.; Souza, L. R. Q.; Vitória, Gabriela; Ornelas, I.; Karmirian, K.; Mendes, M.; Gomes, I.; Sacramento, C.; Fintelman-Rodrigues, N.; Soares, V.; Dias, S.; Salerno, J.; Pijuan, T. P.; Oliveira, J. T.; Aragao, L.; Torquato, T.; Verissimo, C.; Biagi, D.; Cruvinel, E. M.; Dariolli, R.; Furtado, D.R.; Borges, H. L.; Bozza, P.; Rehen, S. K.; Souza, T. M.; Guimaraes, M. Z. P. Non-permissive SARS-CoV-2 infection in human neurospheres. Stem Cell Research. , v.54, p.102436 – , 2021.
A clinical score to predict mortality in septic acute kidney injury patients requiring continuous renal replacement therapy: the HELENICC score
Inclusion and definition of acute renal dysfunction in critically ill patients in randomized controlled trials: a systematic review
Ultrasound-based clinical profiles for predicting the risk of intradialytic hypotension in critically ill patients on intermittent dialysis: a prospective observational study
Trindade P, Nascimento JM, Casas BS, Monteverde T, Gasparotto J, Ribeiro CT, Devalle S, Sauma D, Moreira JCF, Gelain DP, Porciuncula LO, Palma V, Martins-de-Souza D, Rehen SK. Induced pluripotent stem cell-derived astrocytes from patients with schizophrenia exhibit an inflammatory phenotype that affects vascularization. Mol Psychiatry. 2022 Oct 24.
Ornelas IM, Cini FA, Wießner I, Marcos E, Araújo DB, Goto-Silva L, Nascimento J, Silva SRB, Costa MN, Falchi M, Olivieri R, Palhano-Fontes F, Sequerra E, Martins-de-Souza D, Feilding A, Rennó-Costa C, Tófoli LF, Rehen SK, Ribeiro S. Nootropic effects of LSD: Behavioral, molecular and computational evidence. Exp Neurol. 2022 Oct;356:114148
Fischer, R. & Karl, J.A. (2022). Unravelling values and wellbeing – disentangling within- and between-person dynamics via a psychometric network perspective.
Fischer, R., Karl, J. A., & Pilati, R. (2022). Cultural Syndromes in a Changing World: A Longitudinal Investigation of Brazilian Jeitinho Social Problem-Solving Strategies.
Sneddon, J., Daniel, E., Fischer, R., & Lee, J.A. (2022). The impact of the COVID-19 pandemic on environmental values
Lourenco MV, Frozza RL, de Freitas GB, Zhang H, Kincheski GC, Ribeiro FC, Gonçalves RA, Clarke JR, Beckman D, Staniszewski A, Berman H, Guerra LA, Forny-Germano L, Meier S, Wilcock DM, de Souza JM, Alves-Leon S, Prado VF, Prado MAM, Abisambra JF, Tovar-Moll F, Mattos P, Arancio O, Ferreira ST, De Felice FG. Exercise-linked FNDC5/irisin rescues synaptic plasticity and memory defects in Alzheimer’s models. Nat Med. 2019 Jan;25(1):165-175. doi: 10.1038/s41591-018-0275-4. Epub 2019 Jan 7. PMID: 30617325; PMCID: PMC6327967.
de Oliveira-Souza R, Moll J. Moral conduct and social behavior. In: M D’Esposito & J Grafman (Editors) Handbook of Clinical Neurology, Third Series: The Frontal Lobes. New York, NY: Elsevier, 2019: 295-315
Oliveira MM, Lourenco MV, Longo F, Kasica N, Yang W, Ureta G, Ferreira DDP, Mendonça PHJ, Bernales S, Ma T, De Felice FG, Klann E, Ferreira ST (2021) Correction of eIF2-dependent defects in brain protein synthesis, synaptic plasticity and memory in mouse models of Alzheimer’s disease. Science Signal. 14(668): eabc5429.
Tahira AC, Verjovski-Almeida S, Ferreira ST (2021) Dementia is an age-independent risk factor for severity and death in COVID-19 inpatients. Alzheimers Dement. 2021 Apr 21.
Pedrosa CDSG, Souza LRQ, Gomes TA, de Lima CVF, Ledur PF, Karmirian K, Barbeito-Andres J, Costa MDN, Higa LM, Rossi ÁD, Bellio M, Tanuri A, Prata-Barbosa A, Tovar-Moll F, Garcez PP, Lara FA, Molica RJR, Rehen SK. The cyanobacterial saxitoxin exacerbates neural cell death and brain malformations induced by Zika virus. PLoS Negl Trop Dis. 2020 Mar 12;14(3):e0008060.
Garcez PP, Loiola EC, Madeiro da Costa R, Higa LM, Trindade P, Delvecchio R, Nascimento JM, Brindeiro R, Tanuri A, Rehen SK. Zika virus impairs growth in human neurospheres and brain organoids. Science. 2016 May 13;352(6287):816-8.
Dakic V, Minardi Nascimento J, Costa Sartore R, Maciel RM, de Araujo DB, Ribeiro S, Martins-de-Souza D, Rehen SK. Short term changes in the proteome of human cerebral organoids induced by 5-MeO-DMT. Sci Rep. 2017 Oct 9;7(1):12863.
Calil V, Souza AS, Sudo FK, Santiago-Bravo G, Assunção N, Drummond C, et al. Anosognosia for memory in dementia with Lewy bodies compared with Alzheimer’s disease. International Journal of Geriatric Psychiatry 2021; 36(7):1059-1064.
Sudo FK, de Souza AS, Drummond C, Assuncao N, Teldeschi A, Oliveira N, et al. Inter-method and anatomical correlates of episodic memory tests in the Alzheimer’s Disease spectrum. PLoS ONE 2019; 14(10): e0223731.
Drummond C, Coutinho G, Monteiro MC, Assuncao N, Teldeschi A, de Souza AS, Oliveira N, Bramati I, Sudo FK, Vanderboght B, Brandao CO, Fonseca RP, de Oliveira-Souza R, et al. Narrative impairment, white matter damage and CSF biomarkers in the Alzheimer’s disease spectrum. Aging (Albany NY). 2019;11:9188-9208.
Souza AS, Oliveira-Szjenfeld PS, Melo ASO, Souza LAM, Batista AGM, Tovar-Moll F. Imaging findings in congenital Zika virus infection syndrome: an update. Child’s Nervous System 2018; 34:85-93.
Silveira de Souza A., de Oliveira-Souza R., Moll J., Tovar-Moll F., Andreiuolo P.A., Bottino C.M.C.. Contribution of 1H Spectroscopy to a Brief Cognitive-Functional Test Battery for the Diagnosis of Mild Alzheimer’s Disease. Dement Geriatr Cogn Disord 2011;32:351–361.
Nonaka CKV, Franco MM, Gräf T, de Lorenzo Barcia CA, de Ávila Mendonça RN, de Sousa KAF, Neiva LMC, Fosenca V, Mendes AVA, de Aguiar RS, Giovanetti M, de Freitas Souza BS. Genomic Evidence of SARS-CoV-2 Reinfection Involving E484K Spike Mutation, Brazil. Emerg Infect Dis. 2021 May;27(5):1522-1524.Epub 2021 Feb 19. PMID: 33605869; PMCID: PMC8084516.
Improta Caria, A.C.; Nonaka, C.K.V.; Pereira, C.S.; Soares, M.B.P.; Macambira, S.G.; Souza, B.S.d.F. Exercise Training-Induced Changes in MicroRNAs: Beneficial Regulatory Effects in Hypertension, Type 2 Diabetes, and Obesity. Int. J. Mol. Sci. 2018, 19, 3608.
Nonaka, C.K.V.; Macêdo, C.T.; Cavalcante, B.R.R.; Alcântara, A.C.d.; Silva, D.N.; Bezerra, M.d.R.; Caria, A.C.I.; Tavora, F.R.F.; Neto, J.D.d.S.; Noya-Rabelo, M.M.; Rogatto, S.R.; Ribeiro dos Santos, R.; Souza, B.S.d.F.; Soares, M.B.P. Circulating miRNAs as Potential Biomarkers Associated with Cardiac Remodeling and Fibrosis in Chagas Disease Cardiomyopathy. Int. J. Mol. Sci. 2019, 20, 4064.
Nonaka, C.K.V.; Sampaio, G.L.; de Aragão França, L.; Cavalcante, B.R.; Silva, K.N.; Khouri, R.; Torres, F.G.; Meira, C.S.; de Souza Santos, E.; Macedo, C.T.; Paredes, B.D.; Rocha, V.P.C.; Rogatto, S.R.; Ribeiro dos Santos, R.; Souza, B.S.d.F.; Soares, M.B.P. Therapeutic miR-21 Silencing Reduces Cardiac Fibrosis and Modulates Inflammatory Response in Chronic Chagas Disease. Int. J. Mol. Sci. 2021, 22, 3307.
Evangelista, A.F., Vannier-Santos, M.A., de Assis Silva, G.S. et al. Bone marrow-derived mesenchymal stem/stromal cells reverse the sensorial diabetic neuropathy via modulation of spinal neuroinflammatory cascades. J Neuroinflammation 15, 189 (2018).
Vieira, T. ; Carvalho, T. L. ; Oliveira, L. A. S. ; Horsczaruk, C. H. ; Freitas, G. R. ; Tovar-Moll, F ; Rodrigues, E.C. Postural Muscle Unit Plasticity in Stroke Survivors: Altered Distribution of Gastrocnemius’ Action Potentials. Frontiers in Neurology, v. 10, p. 686, 2019.
Marins, T. ; Rodrigues, E.C. ; Bortolini, T. ; Melo, Bruno ; Moll, J. ; Tovar-Moll, F. . Structural and Functional Connectivity Changes in Response to Short-term Neurofeedback Training with Motor Imagery. Neuroimage, v. 194, p. 283, 2019.
Oliveira, LA ; Martins, C. ; Horsczaruk, C.H.R. ; Silva, D.C.S ; Vasconcellos, L. F. ; Lopes, A. J. ; Mainenti, M. R. M. ; Rodrigues, E.C. . Partial Body Weight-Supported Treadmill Training in Spinocerebellar Ataxia. Rehabilitation Research and Practice, v. 2018, p. 1-8, 2018.
Tovar-Moll, F. ; Monteiro, M. ; Andrade, J. ; Bramati, I. E. ; Vianna-Barbosa, R. ; Marins, T. ; Rodrigues, E. C. ; Dantas, N. ; Behrens, T. E. J. ; De Oliveira-Souza, R. ; Moll, J. ; Lent, R. . Structural and functional brain rewiring clarifies preserved interhemispheric transfer in humans born without the corpus callosum. Proceedings of the National Academy of Sciences of the United States of America, v. 111, p. 7843, 2014.
Caldas JR, Panerai RB, Passos R, Hajjar LA. Is there still a place for transcranial Doppler in patients with IABP? Crit Care. 2020 Oct 23;24(1):625. PMID: 33097067; PMCID: PMC7585289.
Caldas JR, Passos RH, Ramos JGR, Ramalho C, Sancho LS, Salinet AM, Farias S, Gobatto A, Bombonato G, Benigno P, Taccone FS, Panerai RB. Dynamic Autoregulation is Impaired in Circulatory Shock. Shock. 2020 Aug;54(2):183-189. PMID: 31764617.
Caldas JR, Panerai RB, Bor-Seng-Shu E, Ferreira GSR, Camara L, Passos RH, Salinet AM, Azevedo DS, de-Lima-Oliveira M, Galas FRBG, Fukushima JT, Nogueira R, Taccone FS, Landoni G, Almeida JP, Robinson TG, Hajjar LA. Intra-aortic balloon pump does not influence cerebral hemodynamics and neurological outcomes in high-risk cardiac patients undergoing cardiac surgery: an analysis of the IABCS trial. Ann Intensive Care. 2019 Nov 27;9(1):130. PMID: 31773324; PMCID: PMC6879692.
Caldas JR, Panerai RB, Bor-Seng-Shu E, Ferreira GSR, Camara L, Passos RH, de-Lima-Oliveira M, Galas FRBG, Almeida JP, Nogueira RC, Mian N, Gaiotto FA, Robinson TG, Hajjar LA. Dynamic cerebral autoregulation: A marker of post-operative delirium? Clin Neurophysiol. 2019 Jan;130(1):101-108. Epub 2018 Nov 22. PMID: 30503909; PMCID: PMC7106549.
Rocha Ferreira GS, de Almeida JP, Landoni G, Vincent JL, Fominskiy E, Gomes Galas FRB, Gaiotto FA, Dallan LO, Franco RA, Lisboa LA, Palma Dallan LR, Fukushima JT, Rizk SI, Park CL, Strabelli TM, Gelas Lage SH, Camara L, Zeferino S, Jardim J, Calvo Arita ECT, Caldas Ribeiro J, Ayub-Ferreira SM, Costa Auler JO Jr, Filho RK, Jatene FB, Hajjar LA. Effect of a Perioperative Intra-Aortic Balloon Pump in High-Risk Cardiac Surgery Patients: A Randomized Clinical Trial. Crit Care Med. 2018 Aug;46(8):e742-e750. PMID: 29727370.
Allahdadi KJ, de Santana TA, Santos GC, Azevedo CM, Mota RA, Nonaka CK, Silva DN, Valim CXR, Figueira CP, Dos Santos WLC, do Espirito Santo RF, Evangelista AF, Villarreal CF, Dos Santos RR, de Souza BSF, Soares MBP. IGF-1 overexpression improves mesenchymal stem cell survival and promotes neurological recovery after spinal cord injury. Stem Cell Res Ther. 2019 May 21;10(1):146. PMID: 31113444; PMCID: PMC6530133.
SOUZA, BRUNO SOLANO DE FREITAS; SILVA, DANIELA NASCIMENTO; CARVALHO, REJANE HUGHES; SAMPAIO, GABRIELA LOUISE DE ALMEIDA; PAREDES, BRUNO DIAZ; ARAGÃO FRANÇA, LUCIANA; AZEVEDO, CARINE MACHADO; VASCONCELOS, JULIANA FRAGA; MEIRA, CASSIO SANTANA; NETO, PAULO CHENAUD; MACAMBIRA, SIMONE GARCIA; DA SILVA, KÁTIA NUNES; ALLAHDADI, KYAN JAMES; TAVORA, FABIO; DE SOUZA NETO, JOÃO DAVID; DOS SANTOS, RICARDO RIBEIRO; SOARES, MILENA BOTELHO PEREIRA Association of Cardiac Galectin-3 Expression, Myocarditis, and Fibrosis in Chronic Chagas Disease Cardiomyopathy. AMERICAN JOURNAL OF PATHOLOGY. , v.187, p.1134 – 1146, 2017.
Moll, Jorge; Zahn, Roland; de Oliveira-Souza, Ricardo; Krueger, Frank; Grafman, Jordan. The neural basis of human moral cognition. Nature Reviews Neuroscience 6 (10), 799-809, 2005.
Moll, Jorge; de Oliveira-Souza, Ricardo; Eslinger, Paul J.; Bramati, Ivanei E. et al. The neural correlates of moral sensitivity: a functional magnetic resonance imaging investigation of basic and moral emotions. The Journal of Neuroscience, 22 (7), 2730-2736, 2002.
Moll, Jorge; Krueger, Frank; Zahn, Roland; Pardini, Matteo; de Oliveira-Souza, Ricardo; Grafman, Jordan. Human fronto–mesolimbic networks guide decisions about charitable donation. Proceedings of the National Academy of Sciences 103 (42), 15623-15628, 2006.
Moll, J, de Oliveira-Souza R, Basilio R, Bramati IE, Gordon B, Rodríguez-Nieto G, Zahn R, Krueger F, Grafman J. Altruistic decisions following penetrating traumatic brain injury. Brain 141(5), 1558-1569, 2018.
Brockington, G, Moreira, APG, Busoc, MS, da Silva SG, Altszylerg E, Fischerh R, and Moll J. Storytelling increases oxytocin and positive emotions and decreases cortisol and pain in hospitalized children. Proceedings of the National Academy of Sciences, 118(22):e2018409118, 2021.
Yücel M, Lee RSC, Fontenelle LF. A New Consensus Framework for Phenotyping and Treatment Selecting in Addiction and Obsessive-Compulsive-Related Disorders. JAMA Psychiatry. 2021 Jul 1;78(7):699-700.
Brierley ME, Thompson EM, Albertella L, Fontenelle LF. Lifestyle interventions in the treatment of Obsessive-Compulsive and Related Disorders: A systematic review. Psychosom Med. 2021 Jul 23.
Fontenelle LF, Albertella L, Brierley ME, Thompson EM, Destrée L, Chamberlain SR, Yücel M. Correlates of obsessive-compulsive and related disorders symptom severity during the COVID-19 pandemic. J Psychiatr Res. 2021 Apr 13:S0022-3956(21)00198-9.
Fontenelle LF, Destrée L, Brierley ME, Thompson EM, Yücel M, Lee R, Albertella L, Chamberlain SR. The place of obsessive-compulsive and related disorders in the compulsive-impulsive spectrum: a cluster-analytic study. CNS Spectr. 2021 Apr 12:1-10.
Thompson EM, Destree L, Albertella L, Fontenelle LF. Internet-Based Acceptance and Commitment Therapy: A Transdiagnostic Systematic Review and Meta-Analysis for Mental Health Outcomes. Behav Ther. 2021 Mar;52(2):492-507.
The World Federation of ADHD International Consensus Statement: 208 Evidence-based conclusions about the disorder. FARAONE S et al. Neuroscience and Biobehavioral Reviews.
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Narrative impairment, white matter damage and CSF biomarkers in the Alzheimer’s disease spectrum. DRUMMOND, CLAUDIA; COUTINHO, Gabriel; MONTEIRO, MARINA CARNEIRO; ASSUNCAO, NAIMA; TELDESCHI, ALINA; DE SOUZA, ANDREA SILVEIRA; OLIVEIRA, NATALIA; BRAMATI, IVANEI; SUDO, FELIPE KENJI; VANDERBOGHT, BART; BRANDAO, CARLOS OTAVIO; FONSECA, ROCHELE PAZ; de Oliveira-Souza, Ricardo; Moll, Jorge; Mattos, Paulo; Tovar-Moll, Fernanda. Aging-US. , v.11, p.9188 – 9208, 2019.
Prado CSC, Lopes PMG, Moll J, DeSalles A, de Oliveira-Souza R. A case of developmental pedophilia unmasked by frontotemporal dementia. Neurocase, 2021; 27 (2): 129-137
de Oliveira-Souza R, Moll J, Zahn R. Moral cognition in neurology. In: Reference Module in Neuroscience and Biobehavioral Psychology. New York, NY: Elsevier, 2020: 1-7
de Oliveira-Souza R, Paranhos T, Moll J, Grafman J. Gender and hemispheric asymmetries in acquired sociopathy. Frontiers in Psychiatry, 2019; 10: 346
de Oliveira-Souza R. Phobia of the supernatural: A distinct but poorly recognized specific phobia with an adverse impact on daily living. Frontiers in Psychiatry, 2018; 9: 590
Moll J, de Oliveira-Souza R, Basílio R, Bramati IE, Gordon B, Rodríguez-Nieto G, Zahn R, Krueger F, Grafman J. Altruistic decisions following penetrating traumatic brain injury. Brain, 2018; 141 (5): 1558-1569
Szczupak D, Liu C, Yen CCC, Choi SH, Meireles F, Victorino C; IRC5 Consortium; Richards L, Lent R, Silva AC, Tovar-Moll F. Long-distance aberrant heterotopic connectivity in a mouse strain with a high incidence of callosal anomalies. Neuroimage. 2020 Aug 15;217:116875. Epub 2020 Apr 23. PMID: 32335262; PMCID: PMC7590260.
Tovar-Moll F, Monteiro M, Andrade J, Bramati IE, Vianna-Barbosa R, Marins T, Rodrigues E, Dantas N, Behrens TE, de Oliveira-Souza R, Moll J, Lent R. Structural and functional brain rewiring clarifies preserved interhemispheric transfer in humans born without the corpus callosum. Proc Natl Acad Sci U S A. 2014 May 27;111(21):7843-8. Epub 2014 May 12. PMID: 24821757; PMCID: PMC4040546.
Andrade-Moraes CH, Oliveira-Pinto AV, Castro-Fonseca E, da Silva CG, Guimarães DM, Szczupak D, Parente-Bruno DR, Carvalho LR, Polichiso L, Gomes BV, Oliveira LM, Rodriguez RD, Leite RE, Ferretti-Rebustini RE, Jacob-Filho W, Pasqualucci CA, Grinberg LT, Lent R. Cell number changes in Alzheimer’s disease relate to dementia, not to plaques and tangles. Brain. 2013 Dec;136(Pt 12):3738-52. Epub 2013 Oct 17. PMID: 24136825; PMCID: PMC3859218.
Lent R, Azevedo FA, Andrade-Moraes CH, Pinto AV. How many neurons do you have? Some dogmas of quantitative neuroscience under revision. Eur J Neurosci. 2012 Jan;35(1):1-9. Epub 2011 Dec 13. PMID: 22151227.
Azevedo FA, Carvalho LR, Grinberg LT, Farfel JM, Ferretti RE, Leite RE, Jacob Filho W, Lent R, Herculano-Houzel S. Equal numbers of neuronal and nonneuronal cells make the human brain an isometrically scaled-up primate brain. J Comp Neurol. 2009 Apr 10;513(5):532-41. doi: 10.1002/cne.21974. PMID: 19226510.
Daniel, E., Bardi, A., Fischer, R., Benish-Weisman, M. & Lee, J.A. (2021). Changes in personal values in pandemic times. Social Psychological and Personality Science.
Brockington, G., Moreira, A. P.G., Buso, M.S., Gomes da Silva, S., Altszyler, E., Fischer, R., & Moll, J. (2021). Storytelling increases oxytocin and positive emotions and decreases cortisol and pain in hospitalized children. Proceedings of the National Academy of Sciences, Jun 2021, 118 (22) e2018409118;
Fischer, R.& Karl, J.A. (2021). Predicting behavioral intentions to prevent or mitigate COVID-19: A cross-cultural meta-analysis of attitudes, norms and perceived behavioral control effects. Social Psychological and Personality Science
Ledo JH, Azevedo EP, Beckman D, Razolli DS, Ribeiro FC, Santos LE, Melo HM, Bellio M, Teixeira AL, Velloso LA, Foguel D, De Felice FG, Ferreira ST (2016) Crosstalk between brain innate immunity and serotonin signaling underlies depressive-like behavior induced by Alzheimer’s amyloid-β oligomers in mice. J. Neurosci. 36:12106-12116
Lourenco MV, Frozza RL, de Freitas GB, Zhang H, Kincheski GC, Clarke JR, Ribeiro FC, Beckman D, Staniszevski A, Berman H, Guerra LA, Forny-Germano L, Meier S, Abisambra JF, Wilcock DM, Prado VF, Prado MAM, de Souza JM, Alves-Leon S, Tovar-Moll F, Mattos P, Arancio O*, Ferreira ST*, De Felice FG* (2019) Exercise-linked FNDC5/irisin rescues synaptic plasticity and memory defects in Alzheimer’s models. Nat. Med. 25(1):165-175.
Figueiredo CP, Barros-Aragão F, Neris RLS, Frost PS, Zamberlan D, Antonio LMS, Soares C, Souza AS, Guimarães ALA, de Souza JM, Alves-Leon SV, De Felice FG, Assunção-Miranda I, Clarke JR, Da Poian AT, Ferreira ST (2019) Zika virus replicates in adult human brain tissue and impairs synapses and memory in mice. Nat. Commun. 2019 Sep 5;10(1):3890.
Gabriela Louise de Almeida Sampaio, Gabriele Louise Soares Martins, Bruno Diaz Paredes, Carolina Kymie Vasques Nonaka, Katia Nunes da Silva, Erik Aranha Rossi, Ricardo Ribeiro dos Santos, Milena Botelho Pereira Soares, Bruno Solano de Freitas Souza. Generation of an induced pluripotent stem cell line from a patient with autism spectrum disorder and SCN2A haploinsufficiency. Stem Cell Research. Volume 39, August 2019, 101488
Bruno S. F. Souza, Gabriela L. A. Sampaio, Ciro S. Pereira, Gubio S. Campos, Silvia I. Sardi, Luiz A. R. Freitas, Claudio P. Figueira, Bruno D. Paredes, Carolina K. V. Nonaka, Carine M. Azevedo, Vinicius P. C. Rocha, Antonio C. Bandeira, Rosalia Mendez-Otero, Ricardo Ribeiro dos Santos & Milena B. P. Soares. Zika virus infection induces mitosis abnormalities and apoptotic cell death of human neural progenitor cells. Scientific reports 6 (1), 1-13. 2016.
Falvella ACB, Smith BJ, Silva-Costa LC, Valença AGF, Crunfli F, Zuardi AW, Hallak JE, Crippa JA, de Almeida V, Martins-de-Souza D. Cannabidiol Displays Proteomic Similarities to Antipsychotics in Cuprizone-Exposed Human Oligodendrocytic Cell Line MO3.13. Front Mol Neurosci. 2021 May 28;14:673144.
Garcia-Rosa S, Carvalho BS, Guest PC, Steiner J, Martins-de-Souza D. Blood plasma proteomic modulation induced by olanzapine and risperidone in schizophrenia patients. Proteomics. 2020 Jul 30;224:103813.
Nascimento JM, Saia-Cereda VM, Sartore RC, da Costa RM, Schitine CS,Freitas HR, Murgu M, de Melo Reis RA, Rehen SK, Martins-de-Souza D.Human Cerebral Organoids and Fetal Brain Tissue Share Proteomic Similarities.Front Cell Dev Biol. 2019 Nov 28;7:303.
Cassoli JS, Brandão-Teles C, G Santana A, H M F Souza G, Martins-de-Souza D. Ion Mobility-Enhanced Data-Independent Acquisitions Enable a Deep Proteomic Landscape of Oligodendrocytes. Proteomics. 2017 Nov;17(21).
Martins-de-Souza D, Maccarrone G, Ising M, Kloiber S, Lucae S, Holsboer F, Turck CW. Blood mononuclear cell proteome suggests integrin and Ras signaling as critical pathways for antidepressant treatment response. Biol Psychiatry. 2014 Oct 1;76(7):e15-7.
Simões EL, Bramati I, Rodrigues E, Franzoi A, Moll J, Lent R, Tovar-Moll F. Functional expansion of sensorimotor representation and structural reorganization of callosal connections in lower limb amputees. J Neurosci. 2012; 32(9), 3211-20.
Tovar-Moll F, Monteiro M, Andrade J, Bramati IE, Vianna-Barbosa R, Marins T, Rodrigues E, Dantas N, Behrens TE, de Oliveira-Souza R, et al. Structural and functional brain rewiring clarifies preserved interhemispheric transfer in humans born without the corpus callosum. Proc Natl Acad Sci U S A. 2014; 111(21), 7843-8.
Soares de Oliveira-Szejnfeld P, Levine D, Melo AS, Amorim MM, Batista AG, Chimelli L, Tanuri A, Aguiar RS, Malinger G, Ximenes R, Robertson R, Szejnfeld J, Tovar-Moll F. Congenital Brain Abnormalities and Zika Virus: What the Radiologist Can Expect to See Prenatally and Postnatally. Radiology. 2016; 1(1), 203-18.
T Marins, EC Rodrigues, T Bortolini, B Melo, J Moll, F Tovar-Moll. Structural and functional connectivity changes in response to short-term neurofeedback training with motor imagery. Neuroimage. 2019;194, 283-290.
Szczupak D, Liu C, Yen CCC, Choi SH, Meireles F, Victorino C; IRC5 Consortium, Richards L, Lent R, Silva AC, Tovar-Moll F. Long-distance aberrant heterotopic connectivity in a mouse strain with a high incidence of callosal anomalies. Neuroimage. 2020 Aug 15;217:116875.
Melo HM, Seixas da Silva GS, Costa B, Clarke JR, Figueiredo CP, Klein WL, Checler F, Velloso LA, Balthazar M, Cintra D, Ferreira ST, De Felice FG*. (2020) Palmitate is increased in the cerebrospinal fluid of humans with obesity and induces memory impairment in mice via pro-inflammatory TNF-α. Cell Reports, 30;2180-2194.
Lourenco MV, Frozza RL, de Freitas GB, Zhang H, Kincheski GC, Clarke JR, Ribeiro FC, Beckman D, Staniszevski A, Berman HL, Guerra LA, Forny-Germano L, Meier S, Abisambra JF, Wilcock DM, Prado VF, Prado MAM, de Souza JM, Alves-Leon SV, Tovar-Moll F, Mattos P, Arancio O, Ferreira ST, De Felice FG. Exercise-linked FNDC5/irisin rescues synapse and memory defects in Alzheimer’s models. Nature Medicine, 25(1):165-175, 2019. Commented in Nature Medicine, Nature Reviews Drug Discovery and Alzforum.
Lourenco MV, Clarke JR, Frozza RL, Bomfim TR, Forny-Germano L, Batista AF, Sathler LB, Brito-Moreira J, Amaral OB, Silva CA, Freitas-Correa L, Espírito-Santo S, Campello-Costa P, Houzel JC, Klein WL, Holscher C, Carvalheira JB, Silva AM, Velloso LA, Munoz DP, Ferreira ST, De Felice FG. TNF-α mediates PKR-dependent memory impairment and brain IRS-1 inhibition induced by Alzheimer’s β-amyloid oligomers in mice and monkeys. Cell Metab, 18(6): 831-843, 2013. Cover story, Commentary in Cell Metab.
Bomfim TR, Forny-Germano L, Sathler LB, Brito-Moreira J, Houzel JC, Decker H, Silverman MA, Kazi H, Melo HM, McClean PL, Holscher C, Arnold SE, Talbot K, Klein WL, Munoz DP, Ferreira ST, De Felice FG. An anti-diabetes agent protects the mouse brain from defective insulin signaling caused by Alzheimer’s disease- associated Aβ oligomers. J Clin Invest, 122(4): 1339-1353, 2012. Commentaries in Nat Rev Neurol, Sci Transl Med and J Clin Invest.
De Felice FG, Tovar-Moll F, Moll J, Munoz DP & Ferreira ST. (2020) Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) and the Central Nervous System. Trends in Neuroscience, 43(6):355-357.